Commercial research

University Research Grants

FORMAS, 1998-2002, Sweden

Swedish Institute, 2003-2006, Visby Program,Ukraine – Belarus - Sweden

EUREKA; Healthy-Weaning, 2002-2004, EU

EUREKA; Lab-Diets, 2002-2004, EU

Vinnova - ERA-Net Transnational Call, 2008 – 2011, EU

SI 2010-2013, Visby Program, Network; Ukraine –Sweden

 

Industrial Research Grants

Gramineer Int. AB (1998 – 2002)

Solvay Pharmaceutical GmbH (2001-2002), Germany

Arexis AB (2004), Sweden

Biovitrum AB (2005), Sweden

Addisseo SAS (2008), France

Alnara Pharm Ltd (2007–2009), USA

Essentys AB (2003–2012), Sweden

Alecresta Inc. (2011 – 2018), USA

FOFIND - RTD Grant (2012- 2015), EU

Allena Pharmaceuticals (2011 - continuum), USA

Polpharma SA (2018 – continuum), Poland

 

Examples of industrial research

Glucose homeostasis dependency on

acini–islet–acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus

 

Alpha-ketoglutarate (AKG)

 

Scientific achievements of Professor Stefan Grzegorz Pierzynowski are strictly related to biological action of alpha-ketoglutarate (AKG). Professor posess essential knowledge of alpha-ketoglutarate (AKG) biological effects e.g., cancer, on bone/cartilage formation, brain function.

Exo-endocrine pancreas regulation

 

Professor Stefan Grzegorz Pierzynowski also concentrate his scientific research on exocrine pancreas regulation in relation to growth, health end development

Relationship between the endocrine and exocrine pancreatic function in sheep, cattle, pigs and rats

 

This subject was profoundly explored using chronic models of pancreas and duodenum fistulation with parallel ganglion nodosus preparation and use of cold reversible blockage of the vagus nerve in healthy and diabetic animals.

 

Animal growth and its relation to development of the pancreas and gut function

 

The research describing the relationship between pancreatic and gut function and development around weaning was evaluated in several PhD-Thesis using animal models and cell models allowing estimation of the effects of pancreatic juice and gut mioelectrical migrating complexes (MMC) on bacteria growth.

 

 

 

Cholecystokinin (CCK) stimulation of the exocrine pancreas via short peptidergic reflexes originating in the duodenum

 

This study led us to the exciting discovery, proven experimentally, that in pigs the CCK dependent pancreatic enzyme secretion is regulated via short peptidergic reflexes originating in the duodenum, and is switched on by CCK produced in the duodenum. The pig model developed for this study incorporated several catheters implanted in different visceral arterial vessels supplying separately the duodenum and/or pancreas which allowed delivery of the hormone (CCK) independently to the duodenum, pancreas and peripheral circulation.

 

 

Gut maturation

 

Study on natural gut development in suckling pigs

 

 

 

 

Macromolecule absorption from the gut

 

Studies were preformed on pigs and rats. Gavages and areolisation models were developed. The efficacy of gut vs. lungs for different drug and metabolic marker absorption in health and acute inflammation were estimated.

 

 

 

 

 

Induction of precocious maturation

 

Studies on the dietary factors trigging precocious maturation of gut and other tissues have been started for some years ago at Lund University on pig and rat model using lectins as stimulators. Lectins enhance the expression of Na/ H+ exchangers in the gut and cause activation of NFκB, which are a direct sign of maturation.

 

 

 

 

Lymph visceral and thoracic duct flow in pigs, sheep and rats

 

Study of cholesterol and drug absorption.

 

 

 

 

 

 

Bile secretion model in pigs and rats

 

Regulation of pancreatic secretion and drug re-circulation e.g., DDVP, etc.

 

 

 

 

 

 

Uricemia model

 

Infusion of uric acid to the peripheral blood and it recovery in portal circulation.

 

 

 

 

 

 

 

Visceral circulation in pigs, sheep and goats

 

Measurement of ghrelin production in the small intestine and stomach

 

 

 

 

 

 

 

Gut electrical activity regulate bacterial growth

 

 

 

 

 

 

 

Skin circulation/perfusion in goats

 

studies on peptide and amino acids utilisation in skin metabolism.

 

 

 

 

 

 

 

Macromolecular absorption from upper respiratory system in pigs

 

Absorption of oxytocin analogues.

 

 

 

 

 

 

 

 

Immunoglobin enriched preterm pig model was achieved.

 

It was proven that in pigs in preterm pigs immunoglobulins treatment is necessary to obtain proper growth and organ (brain, gut function)

 

 

 

 

 

 

 

 

Immunoglobulins and brain development

 

On pig model studies it was proven that immunoglobulins in pig neonates model are indispensable for brain development and integration of it function with peripheral organs e.g., gut , etc.