Glucose homeostasis dependency on
acini–islet–acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus
Scientific achievements of Professor Stefan Grzegorz Pierzynowski are strictly related to biological action of alpha-ketoglutarate (AKG). Professor posess essential knowledge of alpha-ketoglutarate (AKG) biological effects e.g., cancer, on bone/cartilage formation, brain function.
Exo-endocrine pancreas regulation
Professor Stefan Grzegorz Pierzynowski also concentrate his scientific research on exocrine pancreas regulation in relation to growth, health end development
Relationship between the endocrine and exocrine pancreatic function in sheep, cattle, pigs and rats
This subject was profoundly explored using chronic models of pancreas and duodenum fistulation with parallel ganglion nodosus preparation and use of cold reversible blockage of the vagus nerve in healthy and diabetic animals.
Cholecystokinin (CCK) stimulation of the exocrine pancreas via short peptidergic reflexes originating in the duodenum
This study led us to the exciting discovery, proven experimentally, that in pigs the CCK dependent pancreatic enzyme secretion is regulated via short peptidergic reflexes originating in the duodenum, and is switched on by CCK produced in the duodenum. The pig model developed for this study incorporated several catheters implanted in different visceral arterial vessels supplying separately the duodenum and/or pancreas which allowed delivery of the hormone (CCK) independently to the duodenum, pancreas and peripheral circulation.
Animal growth and its relation to development of the pancreas and gut function
The research describing the relationship between pancreatic and gut function and development around weaning was evaluated in several PhD-Thesis using animal models and cell models allowing estimation of the effects of pancreatic juice and gut mioelectrical migrating complexes (MMC) on bacteria growth.
Induction of precocious maturation
Studies on the dietary factors trigging precocious maturation of gut and other tissues have been started for some years ago at Lund University on pig and rat model using lectins as stimulators. Lectins enhance the expression of Na/ H+ exchangers in the gut and cause activation of NFκB, which are a direct sign of maturation.
Study on natural gut development in suckling pigs
Macromolecule absorption from the gut
Studies were preformed on pigs and rats. Gavages and areolisation models were developed. The efficacy of gut vs. lungs for different drug and metabolic marker absorption in health and acute inflammation were estimated.
Lymph visceral and thoracic duct flow in pigs, sheep and rats
Study of cholesterol and drug absorption.
Bile secretion model in pigs and rats
Regulation of pancreatic secretion and drug re-circulation e.g., DDVP, etc.
Infusion of uric acid to the peripheral blood and it recovery in portal circulation.
Visceral circulation in pigs, sheep and goats
Measurement of ghrelin production in the small intestine and stomach
Gut electrical activity regulate bacterial growth
Skin circulation/perfusion in goats
studies on peptide and amino acids utilisation in skin metabolism.
Macromolecular absorption from upper respiratory system in pigs
Absorption of oxytocin analogues.
Preterm pig model
It was proven that in pigs in preterm pigs immunoglobulins treatment is necessary to obtain proper growth and organ (brain, gut function)
Immunoglobulins and brain development
On pig model studies it was proven that immunoglobulins in pig neonates model are indispensable for brain development and integration of it function with peripheral organs e.g., gut , etc.